Affiliation:
1. College of Pharmaceutical Science, Yunnan University of Chinese Medicine, 1076 Yuhua Road, Kunming 650500, China
2. Yunnan
Key Laboratory of Southern Medicine Utilization, 1076 Yuhua Road, Kunming 650500, China
Abstract
Abstract:
Mitochondria regulate a range of important physiological and biochemical cellular processes including
apoptotic cell death, energy production, calcium homeostasis, oxidative stress, and lipid metabolism. Given
their role as the ‘engines’ of cells, their dysfunction is associated with a variety of disease states. Exploring the
relationship between mitochondrial function and disease can reveal the mechanism(s) of drug activity and disease
pathology. In this review, we summarized the methods of evaluating the structure and function of mitochondria,
including the morphology, membrane fluidity, membrane potential, opening of the membrane permeability
transition pore, inner membrane permeabilization, mitochondrial dynamics, mitophagy, oxidative stress,
energy metabolism-related enzymes, apoptotic pathway related proteins, calcium concentration, DNA copy
number, oxygen consumption, β-oxidation-related genes and proteins, cardiolipin content, and adenosine triphosphate
content. We believe that the information presented in this review will help explore the pathological
processes of mitochondria in the occurrence and development of diseases, as well as the activity and mechanism
of drugs, and the discovery of new drugs.
Funder
National Natural Science Foundation of China
Application and Basic Research Project of Yunnan, China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
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