Affiliation:
1. State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou
310027, P.R. China
Abstract
Abstract:
Diabetes has become a serious threat to human health, causing death and pain to numerous patients.
Transdermal insulin delivery is a substitute for traditional insulin injection to avoid pain from the injection.
Transdermal methods include non-invasive and invasive methods. As the non-invasive methods could hardly
get through the stratum corneum, minimally invasive devices, especially microneedles, could enhance the
transappendageal route in transcutaneous insulin delivery, and could act as connectors between the tissue and
outer environment or devices. Microneedle patches have been in quick development in recent years and with
different types, materials and functions. In those patches, the smart microneedle patch could perform as a sensor
and reactor responding to glucose to regulate the blood level. In the smart microneedles field, the phenylboronic
acid system and the glucose oxidase system have been successfully applied on the microneedle platform. Insulin
transdermal delivery strategy, microneedles technology and smart microneedles’ development would be discussed
in this review.
Funder
Natural Science Foundation of Zhejiang Province
Science and Technology Program of Zhejiang Province
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
1 articles.
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