Affiliation:
1. Future Industries Institute, University of South Australia, Mawson Lakes Campus SA 5095, Adelaide SA 5001, Australia
Abstract
Abstract:
Wound healing is a complex and dynamic process that requires intricate synchronization between
multiple cell types within appropriate extracellular microenvironment. Wound healing process involves four
overlapping phases in a precisely regulated manner, consisting of hemostasis, inflammation, proliferation, and
maturation. For an effective wound healing, all four phases must follow in a sequential pattern within a time
frame. Several factors might interfere with one or more of these phases in healing process, thus causing improper
or impaired wound healing resulting in non-healing chronic wounds. The complications associated with
chronic non-healing wounds, along with the limitations of existing wound therapies, have led to the development
and emergence of novel and innovative therapeutic interventions. Nanotechnology presents unique and
alternative approaches to accelerate the healing of chronic wounds by the interaction of nanomaterials during
different phases of wound healing. This review focuses on recent innovative nanotechnology-based strategies
for wound healing and tissue regeneration based on nanomaterials, including nanoparticles, nanocomposites
and scaffolds. The efficacy of the intrinsic therapeutic potential of nanomaterials (including silver, gold, zinc
oxide, copper, cerium oxide, etc.) and the ability of nanomaterials as carriers (liposomes, hydrogels, polymeric
nanomaterials, nanofibers) and therapeutic agents associated with wound-healing applications have also been
addressed. The significance of these nanomaterial-based therapeutic interventions for wound healing needs to
be highlighted to engage researchers and clinicians towards this new and exciting area of bio-nanoscience. We
believe that these recent developments will offer researchers an updated source for the use of nanomaterials as
an advanced approach to improve wound healing.
Funder
NHMRC, National Health and Medical Research Council
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
10 articles.
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