Affiliation:
1. Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan
426-791, South Korea
2. Biomaterials Research Laboratory, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte,
Mangaluru, 575018, India
Abstract
Abstract:
Alginate-based biomaterials have been extensively studied for bone tissue engineering. Scaffolds,
microspheres, and hydrogels can be developed using alginate, which is biocompatible, biodegradable, and able
to deliver growth factors and drugs. Alginate microspheres can be produced using crosslinking, microfluidic,
three-dimensional printing, extrusion, and emulsion methods. The sizes of the alginate microspheres range from
10 μm to 4 mm. This review describes the chemical characterization and mechanical assessment of alginatebased
microspheres. Combinations of alginate with hydroxyapatite, chitosan, collagen, polylactic acid, polycaprolactone,
and bioglass were discussed for bone tissue repair and regeneration. In addition, alginate combinations
with bone morphogenetic proteins, vascular endothelial growth factor, transforming growth factor beta-
3, other growth factors, cells, proteins, drugs, and osteoinductive drugs were analyzed for tissue engineering
applications. Furthermore, the biocompatibility of developed alginate microspheres was discussed for different
cell lines. Finally, alginate microsphere-based composites with stem cell interaction for bone tissue regeneration
were presented. In the present review, we have assessed the preclinical research on in vivo models of alginatebased
microspheres for bone tissue repair and regeneration. Overall, alginate-based microspheres are potential
candidates for graft substitutes and the treatment of various bone-related diseases.
Funder
National Research Foundation (NRF) of Korea
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
9 articles.
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