Affiliation:
1. Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China | Medical College, China Three Gorges University, Yichang 443002, China
Abstract
Background:
As a member of long non-coding RNAs (lncRNAs), maternally expressed gene 8
(MEG8) has been found involving in the progression of a variety of cancers and playing a regulatory role.
Therefore, MEG8 may turn into a new therapeutic target for cancer in the future. The purpose of this review is
to illustrate the molecular mechanism and physiological function of MEG8 in various cancers.
Methods:
We retrieved and analyzed related articles about MEG8, lncRNAs, and cancers, and then summarize
the pathophysiological mechanisms of MEG8 in cancer development.
Results:
LncRNA MEG8 participates in various cancers progression, thus influencing the proliferation, migration,
and invasion of cancers. However, the expression of MEG8 is abnormally upregulated in non-small cell
lung cancer (NSCLC), pancreatic cancer (PC), liver cancer (HCC), pituitary adenoma (PA) and hemangioma
(HA), and inhibited in colorectal cancer (CRC), ovarian cancer (OC) and giant cell tumor (GCT), suggesting its
clinical value in cancer therapy.
Conclusions:
LncRNA MEG8 is expected to be a new therapeutic target or biomarker for a wide range of cancers
in the future.
Funder
National Natural Science Foundation of China
Hubei Province Natural Science Foundation in China
central government guides the special funds for the development of local science and technology
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
3 articles.
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