Affiliation:
1. 1st Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece
2. Department
of Cardiology, St George's University Hospital, London, UK
Abstract
Abstract:
Over 20 years of intensified research in the field of stem cells brought about unprecedented possibilities
in treating heart diseases. The investigators were initially fascinated by the idea of regenerating the lost myocardium
and replacing it with new functional cardiomyocytes, but this was extremely challenging. However,
the multifactorial effects of stem cell-based therapies beyond mere cardiomyocyte generation, caused by
paracrine signaling, would open up new possibilities in treating cardiovascular diseases. To date, there is a
strong body of evidence that the anti-inflammatory, anti-apoptotic, and immunomodulatory effects of stem cell
therapy may alleviate atherosclerosis progression. In the present review, our objective is to provide a brief
overview of the stem cell-based therapeutic options. We aim to delineate the pathophysiological mechanisms of
their beneficial effects in cardiovascular diseases especially in coronary artery disease and to highlight some
conclusions from important clinical studies in the field of regenerative medicine in cardiovascular diseases and
how we could further move onwards.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
2 articles.
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