Epigenetic Effects of Psychoactive Drugs-Reference-Cited by-同舟云学术

Epigenetic Effects of Psychoactive Drugs

Published:2023-08 Issue:27 Volume:29 Page:2124-2139
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Ahmed Rania¹²,Blum Kenneth³,Thanos Panayotis K.¹²

Affiliation:

1. Department of Psychology, State University at Buffalo, Buffalo, NY, USA

2. Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY, USA

3. Division of Addiction Research Education, Center for Sports, Exercise, and Mental Health, Western University Health Sciences, Pomona, CA., USA

Abstract

Abstract: Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in the loss of hundreds of thousands of lives annually. Besides alcohol and opioid use and misuse, there has been an increase in illicit abuse of psychostimulants. Epigenetics is a relatively novel area of research that studies heritable alterations in gene expression. Long-term administration of psychoactive drugs may lead to transcriptional changes in brain regions related to drug-seeking behaviors and rewards that can be passed down transgenerationally. Epigenetic biomarkers such as DNA methylation and histone modifications contribute to disease diagnoses. This review aims to look at the epigenetic modifications brought forth by psychoactive drug abuse.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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