Affiliation:
1. Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of
Meknes, BP 509, Boutalamine, Errachidia, Morocco
Abstract
Abstract:
The pathophysiology of hypertension is often associated with endothelial dysfunction and the impairment
of endothelium-dependent vasodilation mechanisms, as well as alterations in vascular smooth muscle (VSM)
tone. Natural products, particularly alkaloids, have received increased attention in the search for new vasodilator
agents. This review aims to summarize the noteworthy results from ex-vivo and in-vitro studies that explored
the vasodilatory effects of some selected alkaloids (Berberine, Sinomenine, (S)-Reticuline, Neferine, Nuciferine,
Villocarine A, 8-Oxo-9-Dihydromakonakine, Harmaline, Harman, and Capsaicin) and the underlying
mechanisms implicated. The results obtained from the literature revealed that these selected alkaloids exhibited
vasodilation in various vascular models, including mesenteric, carotid, and coronary arteries, thoracic aorta,
and cultured HUCECs and VSMCs. Furthermore, most of these alkaloids induced vasodilation through endothelium-
dependent and endothelium-independent mechanisms, which were primarily mediated by activating
eNOS/NO/sGC/cGMP pathway, opening various potassium (K+) channels, or modulating calcium (Ca2+) channels.
Additionally, several alkaloids exerted vasodilatory effects through multiple mechanism pathways. Moreover,
different alkaloids demonstrated the ability to protect endothelial function by reducing oxidative stress, endoplasmic
reticulum and inflammation. In conclusion, this class of secondary metabolites holds interesting therapeutic
potential in the prevention and treatment of cardiovascular diseases (CVD), particularly hypertension.
Funder
CNRST, Centre National pour la Recherche Scientifique et Technique
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
3 articles.
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