Affiliation:
1. State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, China
Abstract
Background:
Vascular endothelial growth factor (VEGF) is a supergene family derived from a
platelet growth factor. It plays a pivotal role in regulating angiogenesis and lymphangiogenesis. sFlt-1 is a soluble
antagonist of VEGF with an essential effect of maintaining the balance of vascular growth. Recently, sFlt-1
has emerged as a new marker for early diagnosis and disease surveillance of angiogenesis-related diseases.
However, few comprehensive reviews focus on the relationship between sFlt-1 and related diseases despite that
many results have yielded.
Methods:
In this review, we analyzed the relationship between sFlt-1 and angiogenesis-related diseases by
searching PubMed, Web of Science, and other databases, and summarized our current understanding of the role
of sFlt-1 in angiogenesis-related diseases.
Results:
sFlt-1 is associated with pre-eclampsia, perinatal cardiomyopathy, diabetic nephropathy, hypertension,
tumor, atherosclerosis, and other diseases. The mechanisms of sFlt-1 that regulate those diseases are mainly associated
with the bioavailability of VEGF and vascular endothelial cell integrity.
Conclusion:
From the summary article, sFlt-1 is a double regulator in angiogenesis-related diseases; too much
or too little may cause different diseases. Therefore, maintaining the stability of sFlt-1 content in the body is essential
to control the development of related diseases.
Funder
Xinglin Scholar Research Premotion Project of Chengdu University of TCM
Sichuan Provincial Science Technology Department of Youth Science and Technology Innovation Research Team Program
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
6 articles.
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