Electrosprayed Nanoparticles as Drug Delivery Systems for Biomedical Applications

Abstract

Background: Nanotechnology is a tool being used intensely in the area of drug delivery systems in the biomedical field. Electrospraying is one of the nanotechnological methods, which is growing due to its importance in the development of nanoparticles comprising bioactive compounds. It is helpful in improving the efficacy, reducing side effects of active drug elements, and is useful in targeted drug delivery. When compared to other conventional methods like nanoprecipitation, emulsion diffusion, and double emulsification, electrospraying offers better advantages to produce micro/nanoparticles due to its simplicity, cost-effectiveness, and single-step process. Objective: The aim of this paper is to highlight the use of electrosprayed nanoparticles for biomedical applications. Methods: We conducted a literature review on the usage of natural and synthetic materials to produce nanoparticles, which can be used as a drug delivery system for medical purposes. Results: We summarized a possible key role of electrosprayed nanoparticles in different therapeutic applications (tissue regeneration, cancer). Conclusion: The modest literature production denotes that further investigation is needed to assess and validate the promising role of drug-loaded nanoparticles through the electrospraying process as noninvasive materials in the biomedical field.