Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments-Reference-Cited by-同舟云学术

Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments

Published:2021-11-10 Issue:41 Volume:27 Page:4245-4252
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Ferri Clodoveo¹,Giuggioli Dilia¹,Raimondo Vincenzo²,L’Andolina Massimo³,Dagna Lorenzo⁴,Tavoni Antonio⁵,Caso Francesco⁶,Ursini Francesco⁷,Ruscitti Piero⁸,Caminiti Maurizio⁹,Foti Rosario¹⁰,Riccieri Valeria¹¹,Guiducci Serena¹²,Pellegrini Roberta¹³,Zanatta Elisabetta¹⁴,Varcasia Giuseppe¹⁵,Olivo Domenico¹⁶,Gigliotti Pietro¹⁷,Cuomo Giovanna¹⁸,Murdaca Giuseppe¹⁹,Cecchetti Riccardo²⁰,De Angelis Rossella²¹,Romeo Nicoletta²²,Ingegnoli Francesca²³,Cozzi Franco²⁴,Codullo Veronica²⁵,Cavazzana Ilaria²⁶,Colaci Michele²⁷,Abignano Giuseppina²⁸,De Santis Maria²⁹,Lubrano Ennio³⁰,Fusaro Enrico³¹,Rossa Alessandra Della³²,Spinella Amelia¹,Lumetti Federica¹,De Luca Giacomo⁴,Bellando-Randone Silvia¹²,Visalli Elisa¹⁰,Dal Bosco Ylenia¹⁰,Amato Giorgio¹⁰,Giannini Daiana⁵,Bilia Silvia⁵,Masini Francesco¹⁸,Pellegrino Greta¹¹,Pigatto Erika²⁴,Generali Elena²⁹,Mariano Giuseppa Pagano⁹,Pettiti Giorgio²²,Zanframundo Giovanni²⁵,Brittelli Raffaele³³,Aiello Vincenzo³³,Caminiti Rodolfo³³,Scorpiniti Daniela³³,Ferrari Tommaso¹⁵,Campochiaro Corrado⁴,Brusi Veronica⁷,Fredi Micaela³⁴,Moschetti Liala²⁶,Cacciapaglia Fabio³⁵,Gragnani Laura³⁶,Monti Monica³⁶,Lorini Serena³⁶,Paparo Sabrina Rosaria³⁷,Ragusa Francesca³⁷,Mazzi Valeria³⁸,Elia Giusy³⁸,Ferrari Silvia Martina³⁷,Di Cola Ilenia⁸,Vadacca Marta³⁹,Lorusso Sebastiano³⁹,Barsotti Simone³²,Aprile Maria Letizia²⁷,Marco Tasso⁶,Miccoli Mario³⁷,Bosello Silvia⁴⁰,Matucci-Cerinic Marco¹²,D'Angelo Salvatore²⁸,Doria Andrea¹⁴,Franceschini Franco²⁶,Meliconi Riccardo⁷,Iannone Florenzo³⁵,Giacomelli Roberto³⁹,Zignego Anna Linda⁴¹,Fallahi Poupak⁴²,Antonelli Alessandro³⁸

Affiliation:

1. Rheumatology Unit, University of Modena and Reggio Emilia, School of Medicine, Modena, Italy

2. Rheumatology Clinic ‘Madonna dello Scoglio’ Cotronei, Crotone, Italy

3. Rheumatology Outpatient Clinic, ASP- Vibo Valentia-Tropea Hospital, Tropea, Italy

4. Ospedale S. Raffaele, Milano, Italy

5. Clinical Immunology, University of Pisa, Pisa, Italy

6. Rheumatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy

7. Medicine & Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

8. Rheumatology Unit, Department of Biotechnological & Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy

9. UOD Reumatologia-Grande Ospedale Metropolitano, Reggio Calabria, Italy

10. AOU Policlinico Vittorio Emanuele, Catania, Italy

11. Rheumatology, Sapienza-University of Rome, Roma, Italy

12. Rheumatology, University of Florence, Firenze, Italy

13. U.O.C. Medicina Interna “M.Valentini” P.O. Annunziata, Cosenza, Italy

14. Rheumatology, University of Padova, Padova, Italy

15. U.O.S. Reumatologia, Ospedale Castrovillari, Cosenza, Italy

16. Rheumatology Outpatient Clinic, San Giovanni di Dio Hospital, Crotone, Italy

17. U.O.T. Specialistica Ambulatoriale ASP 201, Cosenza, Italy

18. University of Campania, Luigi Vanvitelli, Napoli, Italy

19. Ospedale Policlinico S. Martino-University of Genova, Genova, Italy

20. Ospedale di Portoferraio, Livorno, Italy

21. Rheumatology Clinic, Department of Clinical & Molecular Sciences, Marche Polytechnic University, Ancona, Italy

22. ASO S. Croce e Carle, Cuneo, Italy

23. Rheumatology, University of Milano, Milano, Italy

24. Ospedale “Villa Salus”, Mestre, Italy

25. Rheumatology, Policlinico San Matteo, Pavia, Italy

26. Rheumatology, Spedali Civili di Brescia, Brescia, Italy

27. Rheumatology, University of Catania, Catania, Italy

28. AOR San Carlo di Potenza, Potenza, Italy

29. Humanitas Clinical and Research Center IRCCS, Milano, Italy

30. Rheumatology, Università del Molise, Campobasso, Italy

31. Rheumatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Torino, Italy

32. Rheumatology, University of Pisa, Pisa, Italy

33. Rheumatology Clinic 'Madonna dello Scoglio' Cotronei, Crotone, Italy

34. Rheumatology, Spedali Civili di Brescia, Brescia, Italy; 27 Rheumatology, University of Catania, Catania, Italy

35. UO Reumatologia - DETO, Università di Bari, Bari, Italy

36. University of Florence, Firenze, Italy

37. Department of Clinical and Experimental Medicine, University of Pisa, School of Medicine, Pisa, Italy

38. Department of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, School of Medicine, Pisa, Italy

39. Unità Operativa di Immunoreumatologia - Area Medicina Clinica Policlinico Universitario Campus Bio-Medico di Roma, Roma, Italy

40. Institute of Rheumatology, Università Cattolica del Sacro Cuore, Rome, and Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

41. Department of Clinical Experimental Medicine, Interdepartmental Hepatology Center MASVE, University of Florence, Firenze, Italy

42. Department of Translational Research & New Technologies in Medicine and Surgery, University of Pisa, School of Medicine, Pisa, Italy

Abstract

Background: The Covid-19 pandemic may have a deleterious impact on patients with autoimmune systemic diseases (ASD) due to their deep immune-system alterations. Objective: This study aims to investigate the prevalence of symptomatic Covid-19 and its correlations with both organ involvement and ongoing treatments in a large series of Italian ASD patients during the first wave of pandemic. Methods: Our multicenter telephone 6-week survey included 3,029 unselected ASD patients enrolled at 36 tertiary referral centers of northern, central, and southern Italian macro-areas with different diffusion of the pandemic. Symptomatic SARS-CoV-2 infection was classified as definite Covid-19 (presence of symptoms plus positive oral/nasopharyngeal swabs) or highly suspected Covid-19 (highly suggestive symptoms, in the absence of a swab testing). Results: A significantly higher prevalence of definite plus highly suspected Covid-19 compared to the Italian general population was detected in the whole ASD series (p=.000), as well as in patients from the three macro-areas (p=.000 in all). Statistically higher prevalence of Covid-19 was also found in connective tissue diseases compared to chronic arthritis subgroup (p=.000) and in ASD patients with pre-existing interstitial lung involvement (p=.000). Patients treated with either conventional disease-modifying anti-rheumatic drugs (DMARDs) and/or biological DMARDs showed a significantly lower prevalence of Covid-19 (p=.000 in both). Finally, scleroderma patients undergoing low-dose aspirin showed a significantly lower rate of Covid-19 compared to those without (p=0.003). Conclusion: The higher prevalence of Covid-19 in ASD patients, along with the significant correlations with important clinical features and therapeutic regimens, suggests the need to develop targeted prevention/management strategies during the current pandemic wave.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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