Affiliation:
1. College of Medical Science, China Three Gorges University, Yichang 443002, China
2. College of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China
Abstract
Background:
Long noncoding RNA (lncRNA) fetal-lethal non-coding developmental regulatory
RNA (FENDRR), a newly known lncRNA, has been reported to be abnormally expressed in diverse tumors.
This review is focused on clarifying the mechanism of FENDRR to regulate the biological process of tumors,
affirming its value as a target for tumor therapy.
Methods:
The pathophysiological mechanism of FENDRR acting on tumors has been analyzed and summarized
by reviewing PubMed.
Results:
The expression of lncRNA FENDRR is abnormally altered in clinical cancers, promoting the malignant
transformation of a variety of tumors, including colon cancer, cervical cancer, hepatocellular carcinoma,
prostate cancer, Malignant melanoma, lung cancer, osteosarcoma, breast cancer, etc. Cellular processions, including
proliferation, invasion, apoptosis and migration affected by FENDRR, have been revealed.
Conclusion:
Specific evidences for the involvement of LncRNA FENDRR in cancer regulatory processes suggest
that FENDRR has the potential to be a biomarker or clinical therapeutic target for malignant tumors.
Funder
Health commission of Hubei Province scientific research project in China
Central government guides the special funds for the development of local science and technology
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
5 articles.
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