Affiliation:
1. China Three Gorges University, RenHe Hospital, Yichang, China
2. Department of Biochemistry, China Three Gorges University, Yichang, China
Abstract
Background:
Osteoporosis (OP) is the most common bone disease, which is listed by the World
Health Organization (WHO) as the third major threat to life and health among the elderly. The etiology of OP is
multifactorial, and its potential regulatory mechanism remains unclear. Long non-coding RNAs (LncRNAs) are
the non-coding RNAs that are over 200 bases in the chain length. Increasing evidence indicates that LncRNAs are
the important regulators of osteogenic and adipogenic differentiation, and the occurrence of OP is greatly related
to the dysregulation of the bone marrow mesenchymal stem cells (BMSCs) differentiation lineage. Meanwhile,
LncRNAs affect the occurrence and development of OP by regulating OP-related biological processes.
Methods:
In the review, we summarized and analyzed the latest findings of LncRNAs in the pathogenesis, diagnosis
and related biological processes of OP. Relevant studies published in the last five years were retrieved and
selected from the PubMed database using the keywords of LncRNA and OP.
Results/Conclusion:
The present study aimed to examine the underlying mechanisms and biological roles of
LncRNAs in OP, as well as osteogenic and adipogenic differentiation. Our results contributed to providing new
clues for the epigenetic regulation of OP, making LncRNAs the new targets for OP therapy.
Funder
Hubei Provincial Health Commission Joint Fund Project
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
9 articles.
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