Bench-to-Bedside Theranostics in Nuclear Medicine

Author:

Jokar Narges1,Assadi Majid1ORCID,Yordanova Anna2ORCID,Ahmadzadehfar Hojjat2ORCID

Affiliation:

1. The Persian Gulf Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy (MIRT), Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

2. Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany

Abstract

The optimum selection of the appropriate radiolabelled probe for the right target and the right patient is the foundation of theranostics in personalised medicine. In nuclear medicine, this process is realised through the appropriate choice of radiopharmaceuticals based on molecular biomarkers regarding molecular imaging. Theranostics is developing a strategy that can be used to implement accepted tools for individual molecular targeting, including diagnostics, and advances in genomic molecular knowledge, which has led to identifying theranostics biomaterials that have the potency to diagnose and treat malignancies. Today, numerous studies have reported on the discovery and execution of these radiotracers in personalised medicine. In this review, we presented our point of view of the most important theranostics agents that can be used to treat several types of malignancies. Molecular targeted radionuclide treatment methods based on theranostics are excellent paradigms of the relationship between molecular imaging and therapy that has been used to provide individualised or personalised patient care. Toward that end, a precise planned prospective examination of theranostics must be done to compare this approach to more standard therapies.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Guiding principles on the education and practice of theranostics;European Journal of Nuclear Medicine and Molecular Imaging;2024-03-08

2. Theranostics in Nuclear Medicine;Nanobiotechnology Reports;2023-08

3. Homomultimer Strategy for Improvement of Radiolabeled Peptides and Antibody Fragments in Tumor Targeting;Current Medicinal Chemistry;2022-09

4. Toward radiotheranostics in cancer stem cells: a promising initial step for tumour eradication;Clinical and Translational Imaging;2021-06-22

5. Theranostic Approach in Breast Cancer;Clinical Nuclear Medicine;2021-04-30

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