Role of Histamine as a Peripheral Sympathetic Neuromediator and its Interrelation with Substance P-Reference-Cited by-同舟云学术

Role of Histamine as a Peripheral Sympathetic Neuromediator and its Interrelation with Substance P

Published:2020-10-16 Issue:35 Volume:26 Page:4486-4495
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Atencio Augusto S. Manzo¹^ORCID,de Manzo Flor A. Perez²^ORCID,Velasco Manuel¹^ORCID

Affiliation:

1. Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas, Venezuela

2. Carabobo University, Valencia, Venezuela

Abstract

This article is an educational review about the fundamental aspects related to the proposal of the existence of a peripheral sympathetic reflex regulated by histamine, through its effect on presynaptic H3 type receptors, under the interaction of a sensory neuron that would be mediated by Substance P. In this respect, we consider it useful to highlight the role of histamine, so we discuss some aspects about its history, metabolism, and function, as well as its interaction with H3 type receptors that are considered as neuroreceptors, which define and typify it as a neuromediator at both levels of the nervous system, central and peripheral.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

Reference112 articles.

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