Treatment of Severe Aplastic Anemia with Porcine Anti-Human Lymphocyte Globulin-Reference-Cited by-同舟云学术

Treatment of Severe Aplastic Anemia with Porcine Anti-Human Lymphocyte Globulin

Published:2020-07-05 Issue:22 Volume:26 Page:2661-2667
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Lv Qi¹,Huiqin Zhang¹^ORCID,Na Xiao¹^ORCID,Chunyan Liu¹^ORCID,Zonghong Shao¹^ORCID,Huaquan Wang¹^ORCID

Affiliation:

1. Department of Hematology, General Hospital, Tianjin Medical University, Tianjin 300052, China

Abstract

Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia. Decreased numbers of hematopoietic stem cells and impaired bone marrow microenvironment caused by abnormal immune function describe the major pathogenesis of AA. Hematopoietic stem cell transplantation and immunesuppressive therapy are the first-line treatments for AA. Porcine anti-lymphocyte globulin (p-ALG) is a new product developed in China. Several studies have shown that p-ALG exhibited good therapeutic effects in AA.

Funder

Application Bases and Advanced Technology Research Program of Tianjin

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

Reference72 articles.

1. Killick S.B.; Bown N.; Cavenagh J.; Dokal I.; Foukaneli T.; Hill A.; Hillmen P.; Ireland R.; Kulasekararaj A.; Mufti G.; Snowden J.A.; Samarasinghe S.; Wood A.; Marsh J.C.; Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol 2016,172(2),187-207

2. Scheinberg P.; Young N.S.; How I treat acquired aplastic anemia. Blood 2012,120(6),1185-1196

3. Yang L.; Wang H.; Shao Z.; [Advances in the treatment of severe aplastic anemia]. Zhonghua Xue Ye Xue Za Zhi 2015,36(8),711-715

4. Flynn J.; Cox C.V.; Rizzo S.; Foukaneli T.; Rice K.; Murphy M.; Welsh J.; Rutherford T.R.; Gordon-Smith E.C.; Gibson F.M.; Direct binding of antithymoctye globulin to haemopoietic progenitor cells in aplastic anaemia. Br J Haematol 2003,122(2),289-297

5. Dubey S.; Nityanand S.; Involvement of Fas and TNF pathways in the induction of apoptosis of T cells by antithymocyte globulin. Ann Hematol 2003,82(8),496-499

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Application prospect of low-dose porcine anti-thymocyte globulin in HLA-matched sibling donor transplantation;Hematology;2023-05-23