Affiliation:
1. Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, Karachi-75210, Pakistan
2. Department of Chemistry, The University of Jordan, Amman 11942, Jordan
Abstract
:
Tuberculosis (TB) ranks among the diseases with the highest morbidity rate with significantly high
prevalence in developing countries. Globally, tuberculosis poses the most substantial burden of mortality. Further,
a partially treated tuberculosis patient is worse than untreated; they may lead to standing out as a critical obstacle
to global tuberculosis control. The emergence of multi-drug resistant (MDR) and extremely drug-resistant (XDR)
strains, and co-infection of HIV further worsen the situation. The present review article discusses validated targets
of the bacterial enzyme thymidine monophosphate kinase (TMPK). TMPKMTB enzyme belongs to the nucleoside
monophosphate kinases (NMPKs) family. It is involved in phosphorylation of TMP to TDP, and TDP is
phosphorylated to TTP. This review highlights structure elucidation of TMP enzymes and their inhibitors study
on TMP scaffold, and it also discusses different techniques; including molecular docking, virtual screening, 3DPharmacophore,
QSAR for finding anti-tubercular agents.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
4 articles.
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