Affiliation:
1. School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
Abstract
Solid lipid nanoparticles (SLNs) have shown potential as a novel lipid-based drug delivery system for
the topical applications of innumerable therapeutic compounds. However, the mechanisms governing the absorption
and cellular uptake of SLNs through topical route, along with the mechanism of drug release from SLNs are
still ambiguous, and require further investigation. In addition, the selection of an appropriate dosage
form/formulation base is essential for ease of application of SLNs and to enhance dermal and transdermal
delivery. Upscaling and regulatory approvals are other challenges that may impede the clinical translation of
SLNs. Therefore, this review focusses on different mechanisms involved in skin penetration and cellular uptake
of SLNs. This is followed by a comprehensive discussion on the physicochemical properties of SLNs including
various formulation and dosage form factors, which might influence the absorption of SLNs through the skin.
Finally, translational status with respect to scale-up and regulatory aspects are also discussed. This review will be
useful to researchers with an interest in topical applications of SLNs for the efficient delivery of drugs and
cosmetics.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
32 articles.
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