Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance-Reference-Cited by-同舟云学术

Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance

Published:2019-11-19 Issue:34 Volume:25 Page:3599-3607
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Shehzad Adeeb¹,Ravinayagam Vijaya²,AlRumaih Hamad³,Aljafary Meneerah⁴,Almohazey Dana⁵,Almofty Sarah⁵,Al-Rashid Noor A.¹,Al-Suhaimi Ebtesam A.⁵

Affiliation:

1. Department of Clinical Pharmacy, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

2. Scientific Research & Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

3. College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

4. Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

5. Stem Cell Research Department, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

Abstract

: The in-vitro experimental model for the development of cancer therapeutics has always been challenging. Recently, the scientific revolution has improved cell culturing techniques by applying three dimensional (3D) culture system, which provides a similar physiologically relevant in-vivo model for studying various diseases including cancer. In particular, cancer cells exhibiting in-vivo behavior in a model of 3D cell culture is a more accurate cell culture model to test the effectiveness of anticancer drugs or characterization of cancer cells in comparison with two dimensional (2D) monolayer. This study underpins various factors that cause resistance to anticancer drugs in forms of spheroids in 3D in-vitro cell culture and also outlines key challenges and possible solutions for the future development of these systems.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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