The Relationship Between Prostate Cancer and Metformin Consumption: A Systematic Review and Meta-analysis Study
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Published:2019-07-09
Issue:9
Volume:25
Page:1021-1029
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ISSN:1381-6128
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Container-title:Current Pharmaceutical Design
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language:en
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Short-container-title:CPD
Author:
Ghiasi Bahareh1, Sarokhani Diana2, Najafi Farid3, Motedayen Morteza4, Dehkordi Ali Hasanpour5
Affiliation:
1. Bahareh Ghiasi, Department of Nephrology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran 2. Diana Sarokhani, Research Center for Environmental Determinants of Health (RCEDH), School of Public Health, Kermanshah Uninversity of Medical Sciences, Kermanshah, Iran 3. Farid Najafi, MD PhD, Professor of Epidemiology, Research Center for Environmental Determinants of Health (RCEDH), School of Public Health, Kermanshah Uninversity of Medical Sciences, Kermanshah, Iran 4. Morteza Motedayen, Cardiology Department, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran 5. Ali Hasanpour Dehkordi, Department of Medical-Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Introduction:
Prostate cancer is the most common malignant cancer in men worldwide and after lung
cancer, it is the second leading cause of cancer mortality in men. The purpose of this study was to investigate the
relationship between prostate cancer and metformin consumption in men.
Methods:
The current study is a systematic and meta-analysis review based on the PRISMA statement. To access
the studies of domestic and foreign databases, Iran Medex, SID, Magiran, Iran Doc, Medlib, ProQuest, Science
Direct, PubMed, Scopus, Web of Science and the Google Scholar search engine were searched during the 2009-
2018 period for related keywords. In order to evaluate the heterogeneity of the studies, Q test and I2 indicator
were used. The data were analyzed using the STATA 15.1 software.
Results:
In 11 studies with a sample size of 877058, the odds ratio of metformin consumption for reducing prostate
cancer was estimated at 0.89 (95%CI: 0.67-1.17). Meta-regression also showed there was no significant relationship
between the odds ratio and the publication year of the study. However, there was a significant relationship
between the odds ratio and the number of research samples.
Conclusion:
Using metformin in men reduces the risk of prostate cancer but it is not statistically significant.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
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