Affiliation:
1. Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, New Jersey 08854, United States
Abstract
Background:
Chronic skin wounds and pressure ulcers represent major health care problems in diabetic
individuals, as well as patients who suffered a spinal cord injury. Current treatment methods are only partially
effective and such wounds exhibit a high recurrence rate. Open wounds are at high risk of invasive wound
infections, which can lead to amputation and further disability. An interdisciplinary approach is needed to develop
new and more effective therapies.
Methods:
The purpose of this work is to review recent studies focusing on the use of algal polysaccharides in
commercially available as well as experimental wound dressings. Studies that discuss wound dressings based on
algal polysaccharides, some of which also contain growth factors and even living cells, were identified and included
in this review.
Results and Conclusion:
Algal polysaccharides possess mechanical and physical properties, along with excellent
biocompatibility and biodegradability that make them suitable for a variety of applications as wound dressings.
Furthermore, algal polysaccharides have been used for a dual purpose, namely as wound covering, but also as a
vehicle for drug delivery to the wound site.
Funder
U.S. Department of Defense
United States Department of Education Graduate Assistance in Areas of National Need
National Institute of General Medical Sciences of the National Institutes of Health
New Jersey Commission on Spinal Cord Research
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
20 articles.
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