Affiliation:
1. Key Laboratory of Modern Acoustics (MOE), Department of Physics, Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093, China
2. Department of Engineering Science, University of Oxford, Oxford, United Kingdom
Abstract
As irreplaceable energy sources of minimally invasive treatment, light and sound have, separately, laid
solid foundations in their clinic applications. Constrained by the relatively shallow penetration depth of light,
photodynamic therapy (PDT) typically involves involves superficial targets such as shallow seated skin conditions,
head and neck cancers, eye disorders, early-stage cancer of esophagus, etc. For ultrasound-driven
sonodynamic therapy (SDT), however, to various organs is facilitated by the superior... transmission and focusing
ability of ultrasound in biological tissues, enabling multiple therapeutic applications including treating glioma,
breast cancer, hematologic tumor and opening blood-brain-barrier (BBB). Considering the emergence of theranostics
and precision therapy, these two classic energy sources and corresponding sensitizers are worth reevaluating.
In this review, three typical therapies using light and sound as a trigger, PDT, SDT, and combined
PDT and SDT are introduced. The therapeutic dynamics and current designs of pharmacological sensitizers involved
in these therapies are presented. By introducing both the history of the field and the most up-to-date design
strategies, this review provides a systemic summary on the development of PDT and SDT and fosters inspiration
for researchers working on ‘multi-modal’ therapies involving light and sound.
Funder
Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
37 articles.
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