Affiliation:
1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China
Abstract
:Heat shock protein 90 (Hsp90) plays an essential role in various physiological and pathological processes. It activates client proteins to participate in tumor progression. Blocking Hsp90 could enable effective antitumor effects in many tumor types, such as multiple myeloma and colon cancer. Recently, it has motivated an interest in Hsp90 inhibitors that bind to the N-terminal or C-terminal ATP pocket as antitumor drugs. We reviewed the data from experimental and clinical trials on Hsp90 inhibitors in the treatment of different malignancies to explore and summarize their antitumor mechanisms.
Funder
Wuhan Science and Technology Bureau Jing Liu.
National Basic Research Program of China, 973 program, J.L.
National Natural Science Foundation of China Jing Liu.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
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