Plant Extracts Loaded in Nanostructured Drug Delivery Systems for Treating Parasitic and Antimicrobial Diseases

Author:

Gondim Brenna L.C.1,Oshiro-Júnior João A.1,Fernanandes Felipe H.A.1,Nóbrega Fernanda P.1,Castellano Lúcio R.C.2,Medeiros Ana C.D.1

Affiliation:

1. Laboratorio de Desenvolvimento e Ensaios de Medicamentos, Centro de Ciencias Biologicas e da Saude, Universidade Estadual da Paraiba, R. Baraunas, 351, Cidade Universitaria, Campina Grande, Paraiba, 58429-500, Brazil

2. Grupo de Estudos e Pesquisas em Imunologia Humana, Escola Tecnica de Saude, Universidade Federal da Paraiba, Joao Pessoa, PB, Brazil

Abstract

Background: Plant extracts loaded in nanostructured drug delivery systems (NDDSs) have been reported as an alternative to current therapies for treating parasitic and antimicrobial diseases. Among their advantages, plant extracts in NDSSs increase the stability of the drugs against environmental factors by promoting protection against oxygen, humidity, and light, among other factors; improve the solubility of hydrophobic compounds; enhance the low absorption of the active components of the extracts (i.e., biopharmaceutical classification II), which results in greater bioavailability; and control the release rate of the substances, which is fundamental to improving the therapeutic effectiveness. In this review, we present the most recent data on NDDSs using plant extracts and report results obtained from studies related to in vitro and in vivo biological activities.

Funder

Coordenação de Aperfeiçoamento Pessoal de Nível Superior - Brasil (CAPES) - Finance

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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