The Esophageal Cancer and the PI3K/AKT/mTOR Signaling Regulatory microRNAs: a Novel Marker for Prognosis, and a Possible Target for Immunotherapy-Reference-Cited by-同舟云学术

The Esophageal Cancer and the PI3K/AKT/mTOR Signaling Regulatory microRNAs: a Novel Marker for Prognosis, and a Possible Target for Immunotherapy

Published:2019-03-14 Issue:39 Volume:24 Page:4646-4651
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Javadinia Seyed A.¹,Shahidsales Soodabeh¹,Fanipakdel Azar¹,Mostafapour Asma²,Joudi-Mashhad Mona¹,Ferns Gordon A.³,Avan Amir²

Affiliation:

1. Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2. Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran

3. Department of Medical Education, Brighton and Sussex Medical School Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, United Kingdom

Abstract

The Phosphatidylinositol 3-kinase/AKT/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) pathway has a critical regulatory role in cell biology including translation, transcription, and autophagy. Dysregulation of this pathway is involved in the pathogenesis, development, and prognosis of esophageal cancer that has been assessed in the recent years and its potential as a target in therapy. This report summarizes the current knowledge about PI3K/AKT/mTOR pathway and its cross-talk with a focus on the value of targeting this pathway as a potential therapeutic target in the treatment of esophageal cancer.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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