Affiliation:
1. Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan
2. Shobara City Soryo Clinic, Shobara, Japan
Abstract
Earlier studies have shown that visit-to-visit blood pressure (BP) variability (VVV) served as a significant
independent risk factor of stroke, specifically, in the high-risk elderly of cardiovascular disease (CVD). Although
the mechanism is not clearly understood, arterial remodeling such as carotid artery, coronary artery and
large aortic artery would be a strong moderator in the relationship between VVV and CVD incidence. Recent
studies have provided evidence that VVV predicted the progression of arterial stiffness. While the class of
antihypertensive agents is suggested to be an important determinant of VVV, long-acting calcium channel
blockers use (CCBs) is associated with the reduction of VVV, and thus, is suggested to decrease the arterial
stiffness. Specifically, the relationship between VVV and coronary arterial remodeling has never been
reviewed until now. This article summarizes the recent literature on these topics. In the elderly hypertensives,
strict BP control using CCBs could play a pivotal role in suppressing arterial stiffening via VVV reduction.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
21 articles.
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