Affiliation:
1. Internal Medicine and Endocrinology Department of Fattouma Bourguiba University Hospital, University of Monastir, BP 56 Avenue Taher Haddad, Monastir 5000, Tunisia
Abstract
Background:
Autoimmune diseases result from the interplay of cellular effectors like T and B cells,
regulatory cells in addition to molecular factors like cytokines and regulatory molecules.
Methods:
Different electronic databases were searched in a non-systematic way to find out the literature of interest.
Results:
Pathogenesis of autoimmune diseases involves typical factors such as genetic background including
HLA and non HLA system genes, environmental factors such as infectious agents and inflammatory cells mainly
T and B lymphocytes abnormally activated leading to immune dysfunction. Other recently reported less typical
factors such as micro-RNAs, circular RNAs, myeloperoxidase, vimentine and microbiome dysbiosis seem to be
potential target therapies.
Conclusion:
We aimed in this manuscript to review common factors in the pathogenesis of autoimmune diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
8 articles.
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