Affiliation:
1. Photochemistry Department, National Research Centre, Cairo, Egypt
2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
Abstract
There are four types of pyridopyrimidines namely pyrido[2,3-d], pyrido[3,4-d], pyrido[
4,3-d]pyrimidines, and pyrido[3,2-d]pyrimidines. Different methods of preparation of pyrido[2,3-
d]pyrimidines are summarized. Synthesis of pyrido[2,3-d]pyrimidines can be from pyrimidines derivatives
or pyridine derivatives. We can start from pyrimidine derivatives and build a pyridine ring.
5,7-Diphenylpyrido[2,3-d]pyrimidines 3 and 4 were obtained by the reaction of 6-aminouracil (1)
with α,β-unsaturated ketone. 6-Amino-1,3-dimethyluracil 10 was reacted with an equimolar amount
of Mannich bases 11a-c under an atmosphere of nitrogen to give pyridopyrimidines 14a-c via the
formation of the intermediates 12a-c & 13a-c. 4-Benzylamino derivative 19 could be converted to
pyrido[2,3-d]pyrimidine derivative 20 by the reaction with dimethylformamide/ dimethylacetal. In
the same way, we can start from pyridine derivatives and build a pyrimidine ring. Different reported
biological activities of pyrido[2,3-d]pyrimidines are discussed e.g. selective adenosine kinase inhibitors,
analgesic, anti-inflammatory, antimicrobial and herbicides, selective inhibitor of the tyrosine kinase
activities of the Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor
(VEGF) receptors.
Publisher
Bentham Science Publishers Ltd.
Cited by
10 articles.
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