Affiliation:
1. Glocal School of Pharmacy, Glocal University, Mirzapur Pole, Saharanpur, Uttar Pradesh, India
2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, PO Box 840, Saudi Arabia
Abstract
:
Oxazine analog is a vital class of heterocyclic compounds and has attracted synthetic interest
owing to their wide range of biological activities. Oxazine analogs are valuable in medicinal
organic chemistry and exhibit different varieties of biological activities such as antimicrobial, anticancer,
antimalarial, antitubercular, sedative, anticonvulsant, analgesic, anti-inflammatory, antipyretic,
etc. Oxazine can be derived from benzene by appropriate substitution of carbon atoms of the ring
by nitrogen and oxygen atoms. Nowadays, the development of drug resistance is a key problem, and
to defeat this problem, it is crucial to synthesize novel compounds. So, novel oxazine analogs may
play a crucial role to overcome these problems. Oxazine analogs are prepared by reaction of chalcone
derivatives with thiourea in the presence of alcohol and sodium hydroxide. The present aims of
this review are to give an outline of some different synthetic methods and different types of biological
activities of oxazine analogs. We hope that this review will be motivating for researchers concerned
with oxazine analogs.
Publisher
Bentham Science Publishers Ltd.
Cited by
2 articles.
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