Affiliation:
1. Department of Zoology, Laboratory of Alternative Animal Models, Section of Genetics, Faculty of Life Sciences, Aligarh
Muslim University, Aligarh, 202002, Uttar Pradesh, India
Abstract
Background:
Geraniol is a terpene alcohol occurring in the essential oils of several aromatic
plants. It is commercially used as a fragrance compound in cosmetics and several products of
a household. It possesses a number of biological properties.
Objective:
To study the effect of geraniol on the toxicity induced by paracetamol.
Methods:
In the present study, geraniol at the final concentration of 0.0005, 0.0025, 0.0050 and
0.0075 M was mixed in the diet along with the 0.0075 M of paracetamol and the third instar larvae
of transgenic Drosophila melanogaster (hsp70-lac Z)Bg9 were allowed to feed on it for 24 hrs.
Results:
Larvae exposed to paracetamol along with the various doses of geraniol showed a dosedependent
decrease in the activity of β-galactosidase, tissue damage, oxidative stress markers, DNA
damage and apoptosis. The results suggest that geraniol is potent in reducing the toxicity induced by
paracetamol in the third instar larvae of transgenic Drosophila.
Conclusion:
Hence, it is concluded that paracetamol showed toxic effects in the third instar larvae of
transgenic Drosophila, and geraniol is potent in reducing the toxic effects induced by paracetamol.
Publisher
Bentham Science Publishers Ltd.