Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness-Reference-Cited by-同舟云学术

Systematic Review and Meta-analysis of the Impact of Metabolic Surgery on Hepatic Stiffness

Published:2024-11 Issue:4 Volume:19 Page:236-241
ISSN:1574-8871
Container-title:Reviews on Recent Clinical Trials
language:en
Short-container-title:RRCT

Author:

Jamialahamdi Tannaz¹,Kroh Matthew²,Ashari Sorour¹,Almahmeed Wael³,Jangjoo Ali⁴,Simental-Mendía Luis E⁵,Salehabadi Sepideh⁶,Al-Rasadi Khalid⁷,Sahebkar Amirhossein⁶⁸

Affiliation:

1. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2. Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

3. Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

4. Faculty of Medicine, Surgical Oncology Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

5. Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico

6. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

7. Medical Research Centre, Sultan Qaboos University, Muscat, Oman

8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background: Bariatric surgery is one of the effective therapeutic options for people with obesity and obesity-related co-morbidities. In addition to weight-related co-morbid diseases, including diabetes, hypertension, and hypercholesterolemia, non-alcoholic fatty liver disease (NAFLD) is common in patients with morbid obesity. Bariatric surgery is one of the therapeutic options in the management of NAFLD. Hence, this review focused on the potential role of bariatric surgery on hepatic elasticity measured through shear wave elastography. Methods: A systematic literature search was performed, and the studies regarding heterogeneity were evaluated using the random-effects model. Results: The meta-analysis on 6 trials (3-12 months follow-up) including 350 participants showed a significant reduction of liver elasticity after surgery (WMD: -1.149, 95% CI: -1.767, -0.532, p < 0.001; I2:81.55%). Conclusion: Bariatric surgery is associated with decreased liver elasticity. This improvement could be related to weight loss or other mechanisms of bariatric surgery.

Publisher

Bentham Science Publishers Ltd.