Odd Consequences of Dysglycemia in Acute Coronary Syndrome

Author:

Sundargowda Shruthi A1,Halumane Keerthana S.1,Kadiri Sunil Kumar1,Khobragade Deepak S.2

Affiliation:

1. Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, K.S Layout, Bengaluru, 560111, Karnataka, India

2. Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, Sawangi (M) wardha, 442001, India

Abstract

Background: Ischemic heart disease and coronary artery disease are both considered to be the causative factors for Acute Coronary Syndrome (ACS). Cardiovascular disease is the primary cause of death and illness in individuals with both type 1 and type 2 diabetes. It has been reported that long-term hyperglycemia causes chronic heart disease.Background: Objective: This study aimed to explore the hyperlinks between dysglycemia and acute coronary syndrome. Materials and Methods: Databases specifically designed for medical research, such as PubMed, Medline, Embase, and Google Scholar, were utilized for the study. In addition, data from credible health groups and government authorities were also obtained. Results: It has been reported that long-term hyperglycemia causes chronic heart disease. Individuals with type 1 diabetes mellitus tend to develop Coronary Heart Disease (CHD), especially if they have nephropathy. The correlation between dysglycemia and ACS is intricate, and individual reactions may differ. The relationship between genes and environment is now recognized to be mediated by epigenetic factors through many sorts of responses, which can help explain the link between diabetes and cardiovascular disease. HbA1c, a measure of long-term glycemic management, may independently increase CHD risk; however, this is unclear. Conclusion: Poor glycemic management, oxidative stress, insulin resistance indicators, and lowgrade inflammation may cause cardiovascular disease and diabetes. Optimal management of blood glucose levels and comprehensive cardiovascular care are essential in minimizing the impact of dysglycemia on Acute Coronary Syndrome (ACS) outcomes.

Publisher

Bentham Science Publishers Ltd.

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