Affiliation:
1. Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, K.S Layout, Bengaluru,
560111, Karnataka, India
2. Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute
of Higher Education and Research, Sawangi (M) wardha, 442001, India
Abstract
Background:
Ischemic heart disease and coronary artery disease are both considered to be
the causative factors for Acute Coronary Syndrome (ACS). Cardiovascular disease is the primary
cause of death and illness in individuals with both type 1 and type 2 diabetes. It has been reported
that long-term hyperglycemia causes chronic heart disease.Background:
Objective:
This study aimed to explore the hyperlinks between dysglycemia and acute coronary syndrome.
Materials and Methods:
Databases specifically designed for medical research, such as PubMed,
Medline, Embase, and Google Scholar, were utilized for the study. In addition, data from credible
health groups and government authorities were also obtained.
Results:
It has been reported that long-term hyperglycemia causes chronic heart disease. Individuals
with type 1 diabetes mellitus tend to develop Coronary Heart Disease (CHD), especially if they have
nephropathy. The correlation between dysglycemia and ACS is intricate, and individual reactions
may differ. The relationship between genes and environment is now recognized to be mediated by
epigenetic factors through many sorts of responses, which can help explain the link between diabetes
and cardiovascular disease. HbA1c, a measure of long-term glycemic management, may independently
increase CHD risk; however, this is unclear.
Conclusion:
Poor glycemic management, oxidative stress, insulin resistance indicators, and lowgrade
inflammation may cause cardiovascular disease and diabetes. Optimal management of blood
glucose levels and comprehensive cardiovascular care are essential in minimizing the impact of dysglycemia
on Acute Coronary Syndrome (ACS) outcomes.
Publisher
Bentham Science Publishers Ltd.