Affiliation:
1. Department of Radiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China
2. Department of Urology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China
3. Department of Radiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China | Department of Radiology, Zhongshan Hospital, Fudan University, No 180, Fenglin Road, Xuhui District, Shanghai 200032, China
Abstract
Background:
Evidence of the association between obesity and renal cell carcinoma progression is contradictory. The effects of renal cell carcinoma on fat
distribution are still unknown.
Objective:
The goal of this study was to determine the ability of various forms of fat deposition to predict the Fuhrman nuclear grade of clear cell renal cell
carcinoma [ccRCC].
Methods:
This retrospective study included 320 patients with pathologically proven ccRCC [215 men and 105 women; 263 low-grade ccRCC and 57 highgrade
ccRCC]. Based on computed tomography scans, adipose tissue in various body regions was classified into the perirenal fat area [PFA],
visceral fat area [VFA], total fat area [TFA], subcutaneous fat area [SFA], and hepatic steatosis [HS]. Subsequently, the relative VFA [rVFA] was
computed. Age, sex, body mass index, and maximal tumor diameter were also regarded as clinical factors. Univariate and multivariate logistic
regression studies were conducted to evaluate whether there was an association between body fat composition and the Fuhrman classification and
whether it was related to gender.
Results:
After correcting for age, males with low-grade ccRCC exhibited higher TFA [257.6 vs. 203.0, p = 0.002], VFA [151.6 vs.115.5, p = 0.007], SFA
[106.0 vs. 87.5, p = 0.015], PFA [55.1 vs. 30.4, p < 0.001], and HS [18% vs. 0%, p = 0.031] than those with high-grade ccRCC. There was no
significant difference among rVFA in males. In females, there was no significant difference in any of the parameters. VFA and PFA remained
independent predictors for high-grade ccRCC in males in both the monovariate [VFA: odds ratio [OR] 0.992, 95% confidence interval [CI]
0.987–0.997, p = 0.004; PFA: OR 0.949, 95% CI 0.930–0.970, p < 0.001] and multivariate [VFA: OR 1.028, 95% CI 1.001–1.074, p < 0.001;
PFA: OR 0.878, 95% CI 0.833–0.926, p < 0.001] models.
Conclusion:
Gender-specific adipose tissue in different locations demonstrated varied values for predicting high-grade ccRCC and may be utilized as an
independent predictor of high-grade ccRCC in male patients.
conclusion:
Gender-specific adipose tissue in different locations demonstrated varied values for predicting high-grade ccRCC and may be utilized as an independent predictor of high-grade ccRCC in male patients.
other:
Sex-specific adipose tissue in various places exhibits variable values for high-grade ccRCC prediction.
Funder
Scientific Research Project of Fujian for Youth
Publisher
Bentham Science Publishers Ltd.