Author:
Aboul-Enein Hassan Y.,Antochi Oana Mihaela,Nechifor Gheorghe,Bunaciu Andrei A.
Abstract
Aims:A Fourier Transform Infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of Raspberry Ketone (RK) and Caffeine (CAF) in a nutraceutical formulation.Methods:Conventional KBr-spectra and KBr+0.5 mg Microcrystalline Cellulose (MCC)-spectra were used as the basis for a better determination of active substances in the nutraceutical formulation. A calibration model was developed using caffeine and raspberry ketone standards of varying concentrations in the mid-infrared region (4000-400 cm-1). The Beer-Lambert law was used in data processing.Results:The results indicate that FT-IR spectrometry is applicable to the analytical quantification of RK and CAF in the nutraceutical formulation.Conclusion:The method proposed is simple, precise and not time-consuming compared to the chromatographic methods that are cited in the literature. Quantification is performed in about 10-15 minutes, including sample preparation and spectral acquisition.
Publisher
Bentham Science Publishers Ltd.
Reference29 articles.
1. Moffat AC. Clarke’s Isolation and Identification of Drugs. The Pharmaceutical Society of Great Britain 2nd ed. 1986.
2. Miller BE, Danielson ND, Katon JE. Aqueous infrared pharmaceutical analysis of two choline compounds by flow injection analysis using the circle cell. Appl Spectrosc 1988; 42 : 401-5.
3. McClure WF. Analysis Using Fourier Transforms. Handbook of Near-Infrared Analysis 1992; 181-274.
4. Ciurczak EW, Drennen JK III. Pharmaceutical and medical applications of near- infrared spectroscopy 2001; 73-105.
5. Liu Z, Jiao YH, Zhang DY. Single-sweep polarographic studies on raspberry ketone. Chin J Anal Lab 2003; 22 : 168.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献