Affiliation:
1. Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University,
Kunming, China
2. Pediatrics, First class, 2020 Grade, Kunming Medical University, Kunming, China
Abstract
Abstract:
Obstructive sleep apnea [OSA] is widespread in the population and affects
as many as one billion people worldwide. OSA is associated with dysfunction of the
brain system that controls breathing, which leads to intermittent hypoxia [IH],
hypercapnia, and oxidative stress [OS]. The number of NOD-like receptor family pyrin
domain-containing [NLRP3] inflammasome was increased after IH, hypercapnia, and
OS. NLRP3 inflammasome is closely related to inflammation. NLRP3 inflammasome
causes a series of inflammatory diseases by activating IL-1β and IL-18. Subsequently,
NLRP3 inflammasome plays an important role in the complications of OSA, including
Type 2 diabetes [T2DM], coronary heart disease [CHD], hypertension,
neuroinflammation, and depression. This review will introduce the basic composition
and structure of the NLRP3 inflammasome and focus on the relationship between the
NLRP3 inflammasome and OSA and OSA complications. We can deeply understand
how NLRP3 inflammasome is strongly associated with OSA and OSA complications.
Publisher
Bentham Science Publishers Ltd.