Tumor Mutational Burden as a Biomarker of Immunotherapy Response: An Immunogram Approach in Onco-immunology

Author:

Ansari Afzal12,Ray Suman Kumar1,Sharma Mukul1,Rawal Rakesh3,Singh Pushpendra1

Affiliation:

1. ICMR-National Institute of Research in Tribal Health, Jabalpur, MP, India

2. Kadi Sarva Vishwavidyalaya, Gandhinagar, Gujarat, India

3. Department of Life Science, Gujarat University, Gujarat, India

Abstract

Abstract: Immune checkpoint inhibitors have revolutionized cancer treatment by allowing T cells to reactivate. Tumor mutational burden (TMB) is a biomarker that has emerged as a viable diagnostic for locating patients who would benefit from immunotherapy in particular cancer types. Greater neo-antigens mean more opportunities for T cell identification, and TMB is clinically linked to better immune checkpoint inhibitors. Tumor foreignness is a cancer immunogram, and TMB can be used as a substitute for foreignness. The role of TMB analysis as an independent predictor of immunotherapy response in the context of immune checkpoint inhibitor medications is the subject of this mini-review.

Publisher

Bentham Science Publishers Ltd.

Subject

Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

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