Saponins in the Treatment of Gastrointestinal Tract Cancer-Reference-Cited by-同舟云学术

Saponins in the Treatment of Gastrointestinal Tract Cancer

Published:2023-04-27 Issue: Volume: Page:159-181
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Container-title:Phytonutrients in the Treatment of Gastrointestinal Cancer
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Author:

Chauhdary Zunera¹,Ajmal Shah Muhammad²,Hassan Mehmood Malik³,Saleem Uzma¹,Rasul Azhar³,Mujtaba Shah Ghulam⁴,Khan Ajmal⁵,Al-Harrasi Ahmed⁵,Iqbal Shabnoor³,Bibi Shabana⁶

Affiliation:

1. Government College University,Department of Pharmacology,Faisalabad,Pakistan,

2. Government College University,Department of Pharmacognosy,Faisalabad,Pakistan,

3. Government College University,Department of Zoology,Faisalabad,Pakistan,

4. Hazara University,Department of Botany,Mansehra,Pakistan,

5. University of Nizwa,Natural and Medical Sciences Research Centre,Nizwa,Oman,

6. Yunnan University,Yunnan Herbal Laboratory,Kunming,China,650091,

Abstract

The natural glycosides with triterpenoid or spirostaneaglycones are the saponins, which are associated with a wide range of therapeutic activities, inclusive of gastrointestinal anticancer activities. To promote research and development of novel cytotoxic agents against GIT cancer, this chapter focused on the anticancer potentia l of the naturally occurring triterpenoid and steroidal saponins. The in vitro assays and in vivo studies authenticated the anticancer potential of these compounds through anti-angiogenic, anti-proliferative, anti-metastatic and anti-multidrug resistance activities. The protein targets and signaling cascades behind the anticancer effect of these compounds in GIT cancer are also discussed in this chapter. <br>

Publisher

BENTHAM SCIENCE PUBLISHERS

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