Some Medicinal Chemistry Applications of the QSAR/QSPR Theory-Reference-Cited by-同舟云学术

Some Medicinal Chemistry Applications of the QSAR/QSPR Theory

Published:2023-09-25 Issue: Volume: Page:45-61
ISSN:
Container-title:Advanced Pharmacy
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Author:

Duchowicz Pablo R.¹,Garro-Martínez Juan C.²

Affiliation:

1. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CONICET, UNLP, Diag. 113 y 64, C.C. 16, Sucursal 4, 1900 La Plata, Argentina

2. Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO-SL), CONICET, Departamento de Química, Universidad Nacional de San Luis, Chacabuco 917, 5700 San Luis, Argentina

Abstract

The application of QSAR/QSPR techniques and computer-aided modelling are considered valuable tools to initiate the search for new drugs, and nowadays, these are being intensively used for this purpose. Trustworthy models can provide insight into the structural characteristics that may influence the drug inhibitory activity, drastically improving the success and the pace of the development of more effective drugs with weaker secondary effects. The present book chapter revises and comments on different recent QSAR/QSPR applications conducted in medicinal chemistry field in the last five years (2016-2020), developed on various interesting biological activities and physicochemical properties of drug compounds.

Publisher

BENTHAM SCIENCE PUBLISHERS

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