The Anticancer Journey of Liquiritin: Insights into Its Mechanisms and Therapeutic Prospects-Reference-Cited by-同舟云学术

The Anticancer Journey of Liquiritin: Insights into Its Mechanisms and Therapeutic Prospects

Published:2024-08-19 Issue: Volume:31 Page:
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Bhat Asif Ahmad¹,Moglad Ehssan²,Afzal Muhammad³,Agrawal Neetu⁴,Thapa Riya¹,almalki Waleed Hassan⁵,Kazmi Imran⁶,Alzarea Sami I.⁷,Ali Haider⁸⁹,Sharma Sanjay¹⁰,Singh Sachin Kumar¹¹¹²,Dua Kamal¹²¹³,Gupta Gaurav¹⁴¹⁵

Affiliation:

1. School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Mahal Road, Jaipur, India

2. Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia

3. Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231 Jeddah, 21442, Saudi Arabia

4. Institute of Pharmaceutical Research, GLA University, Mathura, U.P., India

5. Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

6. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

7. Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia

8. Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India

9. Department of Pharmacology, Kyrgyz State Medical College, Bishkek, Kyrgyzstan

10. SVKM’S NMIMS, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Mumbai, MS, 400056, India

11. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India

12. Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia

13. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW2007, Australia

14. School of Pharmacy, Graphic Era Hill University, Dehradun, 248007, India

15. Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates

Abstract

Abstract: Liquiritin (LIQ), a bioactive flavonoid from Glycyrrhiza species, has shown significant potential in cancer therapy. LIQ exhibits potent inhibitory effects on various cancer cell types, including breast, lung, liver, and colon cancers, while demonstrating low toxicity towards healthy cells. Its anticancer mechanisms include inducing cell cycle arrest, promoting apoptosis, and modulating inflammation-related pathways. Additionally, LIQ impedes angiogenesis and enhances the efficacy of conventional chemotherapies through sensitization and synergistic effects with other natural compounds and targeted therapies. These multifaceted actions highlight LIQ as a promising candidate for further development as an anticancer agent. This abstract provides an overview of LIQ's chemistry, biological effects, and underlying mechanisms.

Publisher

Bentham Science Publishers Ltd.