Affiliation:
1. Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International
Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College,
University of South China, Hengyang, Hunan Province 421001, P.R. China
Abstract
Abstract:
The proprotein convertase subtilisin/kexin type 9 (PCSK9) belongs to a member
of the proprotein convertase (PC) family, which is mainly secreted by the liver and
plays a central role in lipid metabolism. Furthermore, PCSK9 plays a multifunctional
role in promoting the inflammatory response, inducing cell apoptosis and pyroptosis and
affecting tumor homeostasis. The brain is the organ with the richest lipid content. Incidentally,
PCSK9 increased in many brain diseases, including brain injury and
Alzheimer’s disease (AD). Consequently, the relationship between PCSK9 and brain diseases
has attracted increasing research interest. Amyloid beta (Aβ) accumulation is the
central and initial event in the pathogenesis of AD. This study focuses on the effects of
PCSK9 on Aβ accumulation in the brain via multiple modalities to explore the potential
role of PCSK9 in AD, which is characterized by progressive loss of brain cells by increasing
Aβ accumulation. The study also explores the new mechanism by which PCSK9
is involved in the pathogenesis of AD, providing interesting and innovative guidance
for the future of PCSK9-targeted therapy for AD.
Publisher
Bentham Science Publishers Ltd.