Affiliation:
1. Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China
2. 7T Magnetic Resonance Imaging Translational Medical Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China
Abstract
Abstract:
The emergence of nanomedicine offers renewed promise in the diagnosis and
treatment of diseases. Due to their unique physical and chemical properties, iron oxide
nanoparticles (IONPs) exhibit widespread application in the diagnosis and treatment of
various ailments, particularly tumors. IONPs have magnetic resonance (MR) T1/T2 imaging
capabilities due to their different sizes. In addition, IONPs also have biocatalytic activity
(nanozymes) and magnetocaloric effects. They are widely used in chemodynamic
therapy (CDT), magnetic hyperthermia treatment (MHT), photodynamic therapy (PDT),
and drug delivery. This review outlines the synthesis, modification, and biomedical applications
of IONPs, emphasizing their role in enhancing diagnostic imaging (including
single-mode and multimodal imaging) and their potential in cancer therapies (including
chemotherapy, radiotherapy, CDT, and PDT). Furthermore, we briefly explore the challenges
in the clinical application of IONPs, such as surface modification and protein adsorption,
and put forward opinions on the clinical transformation of IONPs.
Publisher
Bentham Science Publishers Ltd.