The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem-Reference-Cited by-同舟云学术

The Implication of Hypocretin in Drug Abuse and Arousal in the Brain Stem

Published:2023-12 Issue:12 Volume:30 Page:986-991
ISSN:0929-8665
Container-title:Protein & Peptide Letters
language:en
Short-container-title:PPL

Author:

Kourosh-Arami Masoumeh¹^ORCID,Komaki Alireza²,Gholami Masoumeh³

Affiliation:

1. Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

2. Department of Physiology, Hamadan University of Medical Sciences, Hamadan, Iran

3. Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran

Abstract

Abstract: Hypocretin (orexin, Hcrt) neurons located in the lateral hypothalamus (LH) project widely into the brain and are thus responsible for the physiological action of the hypocretin complex. Hypocretin is involved in both arousal and addiction, and brainstem areas such as the locus coeruleus (LC), paragigantocellularis (PGi), and dorsal raphe (DR) contribute to these functions. In the present review, we focus on the effect of Hcrt on drug abuse and arousal in the brainstem.

Publisher

Bentham Science Publishers Ltd.

Subject

Biochemistry,General Medicine,Structural Biology

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