Biosensors and Bioassays for the Medical Detection of Bacillus
Anthracis and Diagnosis of Anthrax
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Published:2024-07-12
Issue:
Volume:31
Page:
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ISSN:0929-8673
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Container-title:Current Medicinal Chemistry
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language:en
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Short-container-title:CMC
Affiliation:
1. Military Faculty of Medicine, University of Defence, Trebesska 1575, Hradec Kralove CZ-50001, Czech Republic
Abstract
Bacillus anthracis is a causative agent of the highly mortal disease anthrax.
This zoonosis is present in nature, but it is also considered one of the most powerful biological
warfare agents. A timely diagnosis is necessary for proper therapy and setting of
epidemiological countermeasures. Current diagnostic methods should be used in specialized
laboratories or medical facilities because there are only a limited number of methods
suitable as hand-held assays or even point-of-care tests for detecting B. anthracis or
anthrax diagnosis. The lateral flow tests are an exception in this regard, but these tests also
have some limitations. Significant progress has been achieved in point-of-care tests
for B. anthracis detection and anthrax diagnosis in various biosensors and bioassays.
This review focuses on current hand-held and point-of-care tests that can easily prove anthrax
or its causative agent outside the context of specialized facilities.
Publisher
Bentham Science Publishers Ltd.