Potentiality of Nucleoside as Antioxidant by Analysis on Oxidative
Susceptibility, Drug Discovery, and Synthesis
-
Published:2023-11-06
Issue:
Volume:31
Page:
-
ISSN:0929-8673
-
Container-title:Current Medicinal Chemistry
-
language:en
-
Short-container-title:CMC
Affiliation:
1. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, People’s Republic of China
Abstract
Abstract:
Nucleosides are sensitive sites towards oxidations caused by endogenous and
exogenous oxidative resources, and a large number of the produced DNA lesions behave
as pathogenesis event1ually. We herein analyze oxidative modes of nucleosides and
structure-activity relationships of some clinical nucleoside drugs. Together with our previous findings on the inhibitory effects of nucleoside derivatives against DNA oxidation, all these results imply a possibility for nucleoside to be a new member in the family of antioxidants. Then, some novel synthetic routines of nucleoside analogs are collected to reveal the applicability in the construction of nucleoside antioxidants. Therefore, it
is reasonable to envision that the nucleoside antioxidant will be a novel topic in the research of both nucleosides and antioxidants.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献