Affiliation:
1. Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian
116044, China
2. Department of Cardiology, the First Affiliated Hospital of Dalian Medical University,
Dalian 116011, China
Abstract
:
Curcumin is a naturally polyphenolic compound used for hepatoprotective,
thrombosuppressive, neuroprotective, cardioprotective, antineoplastic, antiproliferative,
hypoglycemic, and antiarthritic effects. Kidney disease is a major public health problem
associated with severe clinical complications worldwide. The protective effects of curcumin
against nephrotoxicity have been evaluated in several experimental models. In this
review, we discussed how curcumin exerts its protective effect against renal toxicity and
also illustrated the mechanisms of action such as anti-inflammatory, antioxidant, regulating
cell death, and anti-fibrotic. This provides new perspectives and directions for the
clinical guidance and molecular mechanisms for the treatment of renal diseases by curcumin.
Publisher
Bentham Science Publishers Ltd.