Affiliation:
1. Department of Spine Center, Zhongda Hospital, Medical School, Southeast University, China
2. Department of gynecology and obstetrics, The Affiliated Jiangning Hospital of Nanjing Medical University, China
Abstract
Abstract:
Intervertebral disc degeneration (IDD) is a common musculoskeletal system
disease, which is one of the most important causes of low back pain. Despite the high
prevalence of IDD, current treatments are limited to relieving symptoms, and there are
no effective therapeutic agents that can block or reverse the progression of IDD. Oxidative
stress, the result of an imbalance between the production of reactive oxygen species
(ROS) and clearance by the antioxidant defense system, plays an important role in the
progression of IDD. Polyphenols are antioxidant compounds that can inhibit ROS production,
which can scavenge free radicals, reduce hydrogen peroxide production, and inhibit
lipid oxidation in nucleus pulposus (NP) cells and IDD animal models. In this review,
we discussed the antioxidant effects of polyphenols and their regulatory role in different
molecular pathways associated with the pathogenesis of IDD, as well as the limitations
and future prospects of polyphenols as a potential treatment of IDD.
Publisher
Bentham Science Publishers Ltd.