The Use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization-Reference-Cited by-同舟云学术

The Use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization

Published:2024-02-01 Issue: Volume:31 Page:
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Athanasiou Efstratios¹,Papageorgiou Savvas²³,Dafni Marianna Foteini²⁴,Kelesis Ioannis²⁵,Vasileiou Maria²⁶,Tatsiou Theodora²⁷,Kouveloglou Vasiliki²⁴,Kanatas Panagiotis²¹,Stouras Ioannis²¹,Gatsis Athanasios²⁴,Agiassoti Vasiliki Taxiarchoula²¹,Nasimpian Petros²¹,Dafnoudis Dimitrios²⁸,Degaita Kyriaki⁹,Verras Georgios Ioannis²¹⁰,Alexiou Athanasios¹¹¹²¹³,Papadakis Marios¹⁴,Kamal Mohammad Amjad¹⁵¹⁶¹⁷

Affiliation:

1. Department of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece

2. Cancer Prevention Research Group in Greece, Kifisias Avenue 44, Marousi, Greece

3. Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom

4. Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece

5. School of Medicine, Poznań University of Medical Sciences, Poznań, Poland

6. Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece

7. Department of Biology, University of Crete, Heraklion, Crete, Greece

8. Applied Bioinformatics Master Department, Aristotle University of Thessaloniki, Thessaloniki, Greece

9. Department of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Athens

10. Department of Surgery, General University Hospital of Patras, Patra, Greece

11. University Centre for Research & Development, Chandigarh University, Chandigarh-Ludhiana Highway, Mohali, Punjab, India

12. Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW2770, Australia

13. AFNP Med, Wien1030, Austria

14. Department of Surgery II, University Hospital Witten-Herdecke, Heusnerstrasse 40, University of Witten-Herdecke, 42283, Wuppertal, Germany

15. Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China

16. King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia

17. Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Bangladesh

Abstract

Abstract: Epidemiological trends in cancer research show that lung cancer can affect up to 1 in 15 men and 1 in 17 women. With incidence rates as high as these and significant associated mortality and morbidity, it is no wonder that lung cancer is one of the main areas of research focused on cancer. Advances in targeted treatments and specialized irradiation protocols have allowed the treatment of more advanced cases. However, as the patient numbers grow, so does the need for cancer-preventive strategies. The present narrative review focuses on soy isoflavones' role in the chemoprevention of lung cancer and their possible role in therapeutic adjuncts. Laboratory studies on lung cancer cell lines have shown that isoflavones can induce apoptosis, tamper with the expression of proliferative molecular pathways, and even reduce tumor angiogenesis. Additionally, population-level studies have emerged that correlate the consumption of isoflavonoids with reduced risk for the development of lung cancer. Interestingly enough, the literature also contains small-scale studies with evidence of isoflavones being effective chemotherapeutic adjuncts that are currently understudied. Our literature review underlines such findings and provides a call for the enhancement of research regarding naturally occurring dietary products with possible anticarcinogenic effects.

Publisher

Bentham Science Publishers Ltd.