Affiliation:
1. College of Pharmacy, Alfaisal University, Al Takhassusi Rd, Riyadh 11533, Saudi Arabia
2. Department of
Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, P.O Box 13140, Amman 11942,
Jordan
Abstract
Background:
The main protease (Mpro) is a crucial enzyme for the life cycle of
SARS-CoV-2 and a validated target for the treatment of COVID-19 infection. Natural
products have been a proper alternative for treating viral diseases by modulating different
steps of the life cycle of many viruses.
Objective:
This review article is designed to summarize the cumulative information of
natural-derived Mpro inhibitors that are validated by experimental biological testing.
Methods:
The natural-derived Mpro inhibitors of SARS-CoV-2 that have been discovered
since the emergence of the COVID-19 pandemic are reviewed in this article. Only natural
products with experimental validation are reported in this article. Collected compounds
are classified according to their chemical identity into flavonoids, phenolic acids, quinones, alkaloids, chromones, stilbenes, tannins, lignans, terpenes, and other polyphenolic
and miscellaneous natural-derived Mpro inhibitors.
Conclusion:
These compounds could serve as scaffolds for further lead-structure optimization for desirable potency, a larger margin of safety, and better oral activity.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry