Affiliation:
1. Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences,
Hangzhou, China
Abstract
Introduction:
Breast cancer (BRCA) is one of the leading causes of cancer-related death in women. The improvement of the BRCA risk assessment method is of positive clinical significance. Although many clues showed the potential role of disulfidptosis in BRCA as a novel type of programmed cell death, whether disulfidptosis is involved in BRCA tumorigenesis remains unclear.
Method:
We used LASSO-univariate Cox analysis and multivariate Cox analysis to identify six disulfidptosis-related lncRNAs (DPLs) that correlated with BRCA clinical outcome and confirmed that these DPLs were independent prognostic factors for BRCA
(YTHDF3−AS1, AC002398.1, AL451085.2, AC092718.4, AC097662.1 and
AC053503.5). The BRCA risk prognosis model was subsequently established based on
these DPLs.
Result:
After verifying the model reliability in predicting prognosis, immune infiltration
and somatic mutation analysis showed significant differences in the immune microenvironment and mutation of DPLs by risk stratification. Immunotherapy response and drug
resistance analysis suggest the reference value of DPLs in clinical individualized therapy.
Conclusion:
The abnormal expressions of selected DPLs were further validated by the
BRCA cell line experiment. Our results shed new light on the role of DPLs in BRCA.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
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