Isocarpine as A New Peperidine Alkaloid From Adenocarpus Complicatus With Anticandidal Activity-Reference-Cited by-同舟云学术

Isocarpine as A New Peperidine Alkaloid From Adenocarpus Complicatus With Anticandidal Activity

Published:2021-10-15 Issue: Volume:11 Page:
ISSN:2210-3155
Container-title:The Natural Products Journal
language:en
Short-container-title:NPJ

Author:

Alhilal Mohammad¹,Alhilal Suzan²,Gomha Sobhi³,Ouf Salama⁴

Affiliation:

1. Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum,25240, Turkey

2. Department of Chemistry, Faculty of Science, University of Albaath, Homs, Syria, Erzurum, 25080, Turkey

3. Chemistry Department, Faculty of Science, Cairo University, Giza, 12613, Egypt

4. Botany & Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt

Abstract

Aims: Isolation of Isocarpine From Adenocarpus Complicatus. Background: Adenocarpus Complicatus L. is one of Adenocarpus genus which has about 50 species, from Fabaceae (Papilionaceae) family. This plant found in the Mediterranean basin as southern west part of Europe and North Afric forestes. Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent method: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus Complicatus L., which gross in Syria. The structure of the new compound was determined by UV, IR, EI-Ms, 1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC. Results: The anticandidal activity of isocarpine was screened against 38 Candida strains and showed remarkable inhibitory effect compared with fluconazole as antifungal reference drug. Conclusion: Isocarpine is antifungal agent.

Publisher

Bentham Science Publishers Ltd.

Subject

Complementary and alternative medicine,Drug Discovery

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